The Chilean COVID-19 Genomics Network Biorepository: A Resource for Multi-Omics Studies of COVID-19 and Long COVID in a Latin American Population

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dc.contributor.authorIskra A. Signore
dc.contributor.authorGerardo Donoso
dc.contributor.authorPamela Bocchieri
dc.contributor.authorEduardo A. Tobar-Calfucoy
dc.contributor.authorCristian E. Yáñez
dc.contributor.authorLaura Carvajal-Silva
dc.contributor.authorAndrea X. Silva
dc.contributor.authorCarola Otth
dc.contributor.authorClaudio Cappelli
dc.contributor.authorHéctor Valenzuela Jorquera
dc.contributor.authorDaniela Zapata Contreras
dc.contributor.authorYolanda Espinosa Parrilla
dc.contributor.authorPaula Zúñiga Pacheco
dc.contributor.authorMacarena Fuentes Guajardo
dc.contributor.authorVirginia A. Monardes Ramírez
dc.contributor.authorPia Kochifas Velasquez
dc.contributor.authorChristian A. Muñoz
dc.contributor.authorCristina Dorador
dc.contributor.authorJonathan García Araya
dc.contributor.authorClaudia P. Campillay Véliz
dc.contributor.authorCesar Echeverria
dc.contributor.authorRodolfo Alejandro Santander
dc.contributor.authorLeslie C. Cerpa
dc.contributor.authorMatías F. Martínez
dc.contributor.authorLuis Abel Quiñones
dc.contributor.authorEduardo Roberto Lamoza Galleguillos
dc.contributor.authorJuan Saez Hidalgo
dc.contributor.authorEstefanía Nova-Lamperti
dc.contributor.authorSergio Sanhueza
dc.contributor.authorAnnesi Giacaman
dc.contributor.authorGerardo Acosta Jamett
dc.contributor.authorCristóbal Verdugo
dc.contributor.authorAnita Plaza
dc.contributor.authorClaudio Verdugo
dc.contributor.authorCarolina Selman
dc.contributor.authorRicardo Alejandro Verdugo
dc.contributor.authorAlicia Colombo
dc.date.accessioned2026-03-12T15:12:44Z
dc.date.available2026-03-12T15:12:44Z
dc.date.issued2024
dc.description.abstractAlthough a lack of diversity in genetic studies is an acknowledged obstacle for personalized medicine and precision public health, Latin American populations remain particularly understudied despite their heterogeneity and mixed ancestry. This gap extends to COVID-19 despite its variability in susceptibility and clinical course, where ethnic background appears to influence disease severity, with non-Europeans facing higher hospitalization rates. In addition, access to high-quality samples and data is a critical issue for personalized and precision medicine, and it has become clear that the solution lies in biobanks. The creation of the Chilean COVID-19 Biorepository reported here addresses these gaps, representing the first nationwide multicentric Chilean initiative. It operates under rigorous biobanking standards and serves as one of South America’s largest COVID cohorts. A centralized harmonization strategy was chosen and included unified standard operating procedures, a sampling coding system, and biobanking staff training. Adults with confirmed SARS-CoV-2 infection provided broad informed consent. Samples were collected to preserve blood, plasma, buffy coat, and DNA. Quality controls included adherence to the standard preanalytical code, incident reporting, and DNA concentration and absorbance ratio 260/280 assessments. Detailed sociodemographic, health, medication, and preexisting condition data were gathered. In five months, 2262 participants were enrolled, pseudonymized, and sorted by disease severity. The average Amerindian ancestry considering all participant was 44.0% [SD 15.5%], and this value increased to 61.2% [SD 19.5%] among those who self-identified as Native South Americans. Notably, 279 participants self-identified with one of 12 ethnic groups. High compliance (>90%) in all assessed quality controls was achieved. Looking ahead, our team founded the COVID-19 Genomics Network (C19-GenoNet) focused on identifying genetic factors influencing SARS-CoV-2 outcomes. In conclusion, this bottom-up collaborative effort aims to promote the integration of Latin American populations into global genetic research and welcomes collaborations supporting this endeavor. Interested parties are invited to explore collaboration opportunities through our catalog, accessible online.
dc.description.sponsorshipANID(Grants: ANID COVID0961, ANID COVID0789, ANID COVID1005, ANID COVID0585, ACT210085,FONDECYT 1170446, and FONDECYT 1211480), the Chilean Ministry of Education (Grant: MAG1995),the Interuniversity Center for Healthy Aging (Grant: RED21193), the University of Concepción (Grant:VRID220.085.041-INI), and by the University of Tarapacá(Grant: ESR-UTA2295)
dc.identifier.doi10.3390/genes15111352
dc.identifier.issn20734425
dc.identifier.urihttps://repositorioabierto.uantof.cl/handle/uantof/653
dc.language.isoen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceGenes
dc.titleThe Chilean COVID-19 Genomics Network Biorepository: A Resource for Multi-Omics Studies of COVID-19 and Long COVID in a Latin American Population
dc.typeArticle
oaire.citation.volume15
organization.identifier.rorUniversidad de Antofagasta
uantof.identificator.departmentDepartamento de Tecnología Médica
uantof.identificator.facultyFacultad de Ciencias de la Salud
uantof.identificator.instituteInstituto Antofagasta
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Departamento de Tecnología médica
Departamento de Biotecnología
Instituto Antofagasta