Dietary supplementation of a sulforaphane-enriched broccoli extract protects the heart from acute cardiac stress

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dc.contributor.authorKatherin V. Pereyra
dc.contributor.authorDavid C. Andrade
dc.contributor.authorCamilo Toledo
dc.contributor.authorKarla G. Schwarz
dc.contributor.authorAtenea Uribe-Ojeda
dc.contributor.authorAngélica P. Ríos-Gallardo
dc.contributor.authorRodrigo A. Quintanilla
dc.contributor.authorSamuel Contreras
dc.contributor.authorAndrea Mahn
dc.contributor.authorRodrigo Del Rio
dc.date.accessioned2025-06-17T14:01:42Z
dc.date.available2025-06-17T14:01:42Z
dc.date.issued2020
dc.description.abstractCardiac arrythmias play a critical role in several pathological conditions. Importantly, increased arrhythmic risk is associated with systemic oxidative stress and activation of the autonomic nervous system. Thus, we hypothesized that dietary antioxidant supplementation may help in reducing cardiac stress-induced arrhythmias. Sulforaphane (SFN), an isothiocyanate present in Brassicaceaes, is recognized as a powerful health-promoting compound with known antioxidant properties. Then, we aimed to generate a broccoli extract (BE) enriched in SFN and determine whether oral BE supplementation induced cardio-protection during acute cardiac stress in rats. BE decreases cardiac sympathetic drive and increases parasympathetic cardiac modulation as evidenced by heart rate variability (HRV) shifts. In addition, isoproterenol-induced cardiac stress (a sympathomimetic agent) induced a ~ 4-fold increase in arrhythmia incidence and this effect was almost completely abolished by BE treatment. In conclusion, dietary supplementation with a BE regulates cardiac autonomic drive and protects the heart from acute cardiac stress.
dc.description.sponsorshipFundación para la Innovación Agraria (FIA, PYT-2018–0316) FONDECYT 1180172 the Basal Centre of Excellence in Aging and Regeneration (AFB 170005) Lithium in Health and Disease’ from the Sociedad Química y Minera de Chile (SQM).
dc.identifier.doi10.1016/j.jff.2020.104267
dc.identifier.issn17564646
dc.identifier.urihttps://repositorioabierto.uantof.cl/handle/uantof/520
dc.language.isoen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceJournal of Functional Foods
dc.titleDietary supplementation of a sulforaphane-enriched broccoli extract protects the heart from acute cardiac stress
dc.typeArticle
oaire.citation.volume75
organization.identifier.rorUniversidad de Antofagasta
uantof.identificator.centerCentro de Fisiología y Medicina de Altura
uantof.identificator.facultyFacultad de Ciencias de la Salud
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