Effects of enriched‑potassium diet on cardiorespiratory outcomes in experimental non‑ischemic chronic heart failure
| dc.contributor.author | Karla G. Schwarz | |
| dc.contributor.author | Katherin V. Pereyra | |
| dc.contributor.author | Camilo Toledo | |
| dc.contributor.author | David C. Andrade | |
| dc.contributor.author | Hugo S. Díaz | |
| dc.contributor.author | Esteban Díaz‑Jara | |
| dc.contributor.author | Domiziana Ortolani | |
| dc.contributor.author | Angélica Rios‑Gallardo | |
| dc.contributor.author | Paulina Arias | |
| dc.contributor.author | Alexandra Las Heras | |
| dc.contributor.author | Ignacio Vera | |
| dc.contributor.author | Fernando C. Ortiz | |
| dc.contributor.author | Nibaldo C. Inestrosa | |
| dc.contributor.author | Carlos P. Vio | |
| dc.contributor.author | Rodrigo Del Rio | |
| dc.date.accessioned | 2025-06-17T19:43:47Z | |
| dc.date.available | 2025-06-17T19:43:47Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Background: Chronic heart failure (CHF) is a global health problem. Increased sympathetic outflow, cardiac arrhythmogenesis and irregular breathing patterns have all been associated with poor outcomes in CHF. Several studies showed that activation of the renin-angiotensin system (RAS) play a key role in CHF pathophysiology. Interestingly, potassium (K+) supplemented diets showed promising results in normalizing RAS axis and autonomic dysfunction in vascular diseases, lowering cardiovascular risk. Whether subtle increases in dietary K+ consumption may exert similar effects in CHF has not been previously tested. Accordingly, we aimed to evaluate the effects of dietary K+ supplementation on cardiorespiratory alterations in rats with CHF. Methods: Adult male Sprague–Dawley rats underwent volume overload to induce non-ischemic CHF. Animals were randomly allocated to normal chow diet (CHF group) or supplemented K+ diet (CHF+K+ group) for 6 weeks. Cardiac arrhythmogenesis, sympathetic outflow, baroreflex sensitivity, breathing disorders, chemoreflex function, respiratory–cardiovascular coupling and cardiac function were evaluated. Results: Compared to normal chow diet, K+supplemented diet in CHF significantly reduced arrhythmia incidence (67.8 ± 15.1 vs. 31.0 ± 3.7 events/hour, CHF vs. CHF+K+), decreased cardiac sympathetic tone (ΔHR to propranolol:− 97.4 ± 9.4 vs. − 60.8 ± 8.3 bpm, CHF vs. CHF+K+), restored baroreflex function and attenuated irregular breathing patterns. Additionally, supplementation of the diet with K+ restores normal central respiratory chemoreflex drive and brogates pathological cardio-respiratory coupling in CHF rats being the outcome an improved cardiac function. Conclusion: Our findings support that dietary K+ supplementation in non-ischemic CHF alleviate cardiorespiratory dysfunction. | |
| dc.description.sponsorship | Fondo de Desarrollo Científico y Tecnológico FONDECYT 1180172 and the Basal Centre of Excellence in Aging and Regeneration (AFB 170005; ACE 210009) of Pontificia Universidad Católica de Chile donation of SQM to the Pontificia Universidad Católica de Chile | |
| dc.identifier.doi | 10.1186/s40659-021-00365-z | |
| dc.identifier.issn | 07169760 | |
| dc.identifier.uri | https://repositorioabierto.uantof.cl/handle/uantof/525 | |
| dc.language.iso | en | |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.source | Biological Research | |
| dc.title | Effects of enriched‑potassium diet on cardiorespiratory outcomes in experimental non‑ischemic chronic heart failure | |
| dc.type | Article | |
| oaire.citation.volume | 54 | |
| organization.identifier.ror | Universidad de Antofagasta | |
| uantof.identificator.center | Centro de Investigación en Fisiología y Medicina de Altura | |
| uantof.identificator.department | Departamento Biomédico | |
| uantof.identificator.faculty | Facultad de Ciencias de la Salud |