Chemical Profiling, Antioxidant, Anticholinesterase, and Antiprotozoal Potentials of Artemisia copa Phil. (Asteraceae)

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dc.contributor.authorMaria José Larrazábal-Fuentes
dc.contributor.authorCarlos Fernández-Galleguillos
dc.contributor.authorJenifer Palma-Ramírez
dc.contributor.authorJavier Romero-Parra
dc.contributor.authorKevin Sepúlveda
dc.contributor.authorJorge González
dc.contributor.authorAdrián Paredes
dc.contributor.authorJorge Bórquez
dc.contributor.authorMario J. Simirgiotis
dc.contributor.authorJavier Echeverría
dc.contributor.authorAlexandra Galetović
dc.date.accessioned2025-06-16T15:30:30Z
dc.date.available2025-06-16T15:30:30Z
dc.date.issued2020
dc.description.abstractArtemisia copa Phil. (Asteraceae) (known as copa-copa) is a native species of Chile used as an infusion in traditional medicine by Atacameños people in the Altiplano, highlands of northern Chile. In this research, we have investigated for the first time the cholinesterase inhibition potential against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and the chemical profiling of the infusions prepared from the aerial parts of A. copa by high resolution spectrometry. In addition, total phenolic, total flavonoid content, antioxidant (DPPH, FRAP, and ORAC) and antiprozoal activity were tested. Artemisia copa showed good inhibitory activity against AChE and BChE (3.92 ± 0.08 µg/ml and 44.13 ± 0.10 µg/ml). The infusion displayed a total phenolics content of 155.6 ± 2.9 mg of gallic acid equivalents/g and total flavonoid content of 5.5 ± 0.2 mg quercetin equivalents/g. Additionally, trypanocidal activity against Trypanosoma cruzi was found (LD50 of 131.8 µg/ml). Forty-seven metabolites were detected in the infusion of A. copa including several phenolic acids and flavonoids which were rapidly identified using ultrahigh performance liquid chromatography orbitrap mass spectrometry analysis (UHPLC-Orbitrap-MS) for chemical profiling. The major compounds identified in the infusions were studied by molecular docking against AChE and BChE. The UHPLC-MS fingerprints generated can be also used for the authentication of these endemic species. These findings reveal that A. copa infusions can be used as beverages with protective effects.
dc.description.sponsorshipFONDECYT regular 1180059 MINEDUC-UA project code ANT 1856. post doctorate grant 3190794. CONICYT (PAI/ACADEMIA 79160109)
dc.identifier.doi10.3389/fphar.2020.594174
dc.identifier.issn16639812
dc.identifier.urihttps://repositorioabierto.uantof.cl/handle/uantof/513
dc.language.isoen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceFrontiers in Pharmacology
dc.titleChemical Profiling, Antioxidant, Anticholinesterase, and Antiprotozoal Potentials of Artemisia copa Phil. (Asteraceae)
dc.typeArticle
oaire.citation.volume11
organization.identifier.rorUniversidad de Antofagasta
uantof.identificator.departmentDepartamento de Ciencias de los alimentos
uantof.identificator.departmentDepartamento Biomédico
uantof.identificator.departmentDepartamento de Tecnología Médica
uantof.identificator.departmentDepartamento de Química
uantof.identificator.facultyFacultad de Ciencias de la Salud
uantof.identificator.facultyFacultad de Ciencias Básicas
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