Simultaneous Osseo- and Odontointegration of Titanium Implants: Description of Two Cases in Human and Animal Models and Review of Their Experimental and Clinical Implications

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dc.contributor.authorValdivia-Gandur, Iván
dc.contributor.authorManzanares-Céspedes, María Cristina
dc.contributor.authorAstudillo-Rozas, Wilson
dc.contributor.authorAceituno-Antezana, Oscar
dc.contributor.authorTallón-Walton, Victòria
dc.contributor.authorBeltrán, Víctor
dc.date.accessioned2025-06-23T18:25:38Z
dc.date.available2025-06-23T18:25:38Z
dc.date.issued2024
dc.description.abstractTwo cases of calcified bone and dental tissue integration with titanium implants are presented, along with a review of the literature on their experimental and clinical implications. First, histological analyses of a titanium implant extracted from a patient with iimplant disease revealed the integration of both dental and bone tissue on the implant’s surface. Secondly, a biocompatibility study in an animal model documented two implants in contact with tooth roots. Samples from both animal and human models demonstrated simultaneous osseointegration and dental tissue neoformation, with the latter attributed to the activity of cementoblasts. The literature review confirms the formation of cementum around dental implants in contact with teeth. Certain clinical reports have proposed the insertion of implants into bone sites containing impacted teeth as a conservative treatment alternative, avoiding the need for tooth extraction surgery and demonstrating the successful integration of teeth, bone, and dental implants. Furthermore, the documented natural formation of periodontal tissues around dental implants provided a foundation for tissue engineering studies aimed at realizing implant–bone relationships similar to those of natural bone–tooth structures. The primary challenges remain the long-term preservation of periodontal-like tissue formed on implants and the imparting of functional proprioceptive properties.
dc.description.sponsorshipMINEDUC-UA project, code ANT 22991 National Council for Science and Technology Chile (Conicyt), project REDI170658. The animal experiment results reported were part of a project funded by AVINENT.
dc.identifier.doi10.3390/ma17225555
dc.identifier.issn1996-1944
dc.identifier.urihttps://repositorioabierto.uantof.cl/handle/uantof/537
dc.language.isoen
dc.publisherMDPI
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceMaterials
dc.subjecttitanium implant
dc.subjectOsseointegration
dc.subjectcementoconduction
dc.subjectcementointegration
dc.subjectdental tissue engineering
dc.subjectbiomaterial
dc.titleSimultaneous Osseo- and Odontointegration of Titanium Implants: Description of Two Cases in Human and Animal Models and Review of Their Experimental and Clinical Implications
dc.typeArticle
oaire.citation.issue22
oaire.citation.volume17
organization.identifier.rorhttps://ror.org/04eyc6d95
organization.legalNameUniversidad de Antofagasta
uantof.identificator.departmentDepartamento de Odontología
uantof.identificator.departmentDepartamento Biomédico
uantof.identificator.facultyFacultad de Ciencias de la Salud
uantof.identificator.facultyFacultad de Medicina y Odontología
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