Glutamatergic Receptor Trafficking and Delivery: Role of the Exocyst Complex
| dc.contributor.author | Matías Lira | |
| dc.contributor.author | Rodrigo G. Mira | |
| dc.contributor.author | Francisco J. Carvajal | |
| dc.contributor.author | Pedro Zamorano | |
| dc.contributor.author | Nibaldo C. Inestrosa | |
| dc.contributor.author | Waldo Cerpa | |
| dc.date.accessioned | 2025-05-29T19:22:37Z | |
| dc.date.available | 2025-05-29T19:22:37Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Cells comprise several intracellular membrane compartments that allow them to function properly. One of these functions is cargo movement, typically proteins and membranes within cells. These cargoes ride microtubules through vesicles from Golgi and recycling endosomes to the plasma membrane in order to be delivered and exocytosed. In neurons, synaptic functions employ this cargo tra cking to maintain inter-neuronal communication optimally. One of the complexes that oversee vesicle tra cking and tethering is the exocyst. The exocyst is a protein complex containing eight subunits first identified in yeast and then characterized in multicellular organisms. This complex is related to several cellular processes, including cellular growth, division, migration, and morphogenesis, among others. It has been associated with glutamatergic receptor tracking and tethering into the synapse, providing the molecular machinery to deliver receptor-containing vesicles into the plasma membrane in a constitutive manner. In this review, we discuss the evidence so far published regarding receptor tracking and the exocyst complex in both basal and stimulated levels, comparing constitutive tracking and long-term potentiation-related tracking. | |
| dc.description.sponsorship | BMBF 20150065 Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) 1190620 Center for Excellence in Science and Technology (AFB 170005, PFB 12/2007) Sociedad Química y Minera de Chile (SQM) for special grant “The role of lithium in human health and disease” | |
| dc.identifier.doi | 10.3390/cells9112402 | |
| dc.identifier.issn | 20734409 | |
| dc.identifier.uri | https://repositorioabierto.uantof.cl/handle/uantof/497 | |
| dc.language.iso | en | |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.source | Cells | |
| dc.title | Glutamatergic Receptor Trafficking and Delivery: Role of the Exocyst Complex | |
| dc.type | Article | |
| oaire.citation.volume | 9 | |
| organization.identifier.ror | Universidad de Antofagasta | |
| uantof.identificator.department | Departamento Biomédico | |
| uantof.identificator.faculty | Facultad de Ciencias de la Salud | |
| uantof.identificator.institute | Instituto Antofagasta |