Melatonin relations with respiratory Quotient Weaken on acute exposure to high altitude

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dc.contributor.authorTapia, Marcelo
dc.contributor.authorWulff-Zottele, Cristian
dc.contributor.authorDe Gregorio, Nicole
dc.contributor.authorLang, Moring
dc.contributor.authorVarela, Héctor
dc.contributor.authorSerón-Ferré, María Josefa
dc.contributor.authorVivaldi, Ennio A
dc.contributor.authorAraneda, Oscar F.
dc.contributor.authorSilva-Urra, Juan
dc.contributor.authorGunga, Hanss-Christian
dc.contributor.authorBehn, Claus
dc.date.accessioned2024-04-22T23:08:49Z
dc.date.available2024-04-22T23:08:49Z
dc.date.issued2018
dc.description.abstractHigh altitude (HA) exposure may affect human health and performance by involving the body timing system. Daily variations of melatonin may disrupt by HA exposure, thereby possibly affecting its relations with a metabolic parameter like the respiratory quotient (RQ). Sea level (SL) volunteers (7 women and 7 men, 21.0 ± 2.04 y) were examined for daily changes in salivary melatonin concentration (SMC). Sampling was successively done at SL (Antofagasta, Chile) and, on acute HA exposure, at nearby Caspana (3,270 masl). Saliva was collected in special vials (Salimetrics Oral Swab, United Kingdom) at sunny noon (SMCD) and in the absence of blue light at midnight (SMCN). The samples were obtained after rinsing the mouth with tap water and were analyzed for SMC by immunoassay (ELISA kit; IBL International, Germany). RQ measurements (n = 12) were realized with a portable breath to breath metabolic system (OxiconTM Mobile, Germany), between 8:00 PM and 10:00 PM, once at either location. At SL, SMCD, and SMCN values (mean ± SD) were, respectively, 2.14 ± 1.30 and 11.6 ± 13.9 pg/ml (p < 0.05). Corresponding values at HA were 8.83 ± 12.6 and 13.7 ± 16.7 pg/ml (n.s.). RQ was 0.78 ± 0.07 and 0.89 ± 0.08, respectively, at SL and HA (p < 0.05). Differences between SMCN and SMCD (SMCN–SMCD) strongly correlate with the corresponding RQ values at SL (r = −0.74) and less tight at HA (r = −0.37). Similarly, mean daily SMC values (SMC¯ x) tightly correlate with RQ at SL (r = −0.79) and weaker at HA (r = −0.31). SMCN–SMCD, as well as, SMC¯ x values at SL, on the other hand, respectively, correlate with the corresponding values at HA (r = 0.71 and r = 0.85). Acute exposure to HA appears to loosen relations of SMC with RQ. A personal profile in daily SMC variation, on the other hand, tends to be conserved at HA.
dc.description.sponsorshipFONDECYT Chile 1100161; Bundesministerium für Bildung und Forschung (CHLI2Anb, Domeyko-Center) Germany
dc.identifier.doi10.3389/fphys.2018.00798
dc.identifier.issn1664-042X
dc.identifier.urihttps://repositorioabierto.uantof.cl/handle/uantof/365
dc.language.isoen
dc.publisherFrontiers Media SA
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceFrontiers in Physiology
dc.subjectmelatonin
dc.subjectcircadian rhythm
dc.subjecthigh altitude
dc.subjectrespiratory quotient
dc.subjectbody timekeeping
dc.titleMelatonin relations with respiratory Quotient Weaken on acute exposure to high altitude
dc.typeArticle
oaire.citation.issue798
oaire.citation.volume9
organization.identifier.rorhttps://ror.org/04eyc6d95
organization.legalNameUniversidad de Antofagasta
uantof.identificator.departmentDepartamento de Matemáticas
uantof.identificator.facultyFacultad de Ciencias de la Salud
uantof.identificator.facultyFacultad de Ciencias Básicas
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