Baroreflex and chemoreflex interaction in high-altitude exposure: possible role on exercise performance

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dc.contributor.authorPablo Alvarez Araos
dc.contributor.authorSergio Jiménez
dc.contributor.authorCamila Salazar Ardiles
dc.contributor.authorCristian Núñez Espinosa
dc.contributor.authorValeria Paez
dc.contributor.authorMaria Rodriguez Fernandez
dc.contributor.authorAntoine Raberin
dc.contributor.authorGregoire P. Millet
dc.contributor.authorRodrigo Iturriaga
dc.contributor.authorDavid C. Andrade
dc.date.accessioned2026-01-23T15:36:16Z
dc.date.available2026-01-23T15:36:16Z
dc.date.issued2024
dc.description.abstractThe hypoxic chemoreflex and the arterial baroreflex are implicated in the ventilatory response to exercise. It is well known that long-term exercise training increases parasympathetic and decreases sympathetic tone, both processes influenced by the arterial baroreflex and hypoxic chemoreflex function. Hypobaric hypoxia (i.e., high altitude [HA]) markedly reduces exercise capacity associated with autonomic reflexes. Indeed, a reduced exercise capacity has been found, paralleled by a baroreflex-related parasympathetic withdrawal and a pronounced chemoreflex potentiation. Additionally, it is well known that the baroreflex and chemoreflex interact, and during activation by hypoxia, the chemoreflex is predominant over the baroreflex. Thus, the baroreflex function impairment may likely facilitate the exercise deterioration through the reduction of parasympathetic tone following acute HA exposure, secondary to the chemoreflex activation. Therefore, the main goal of this review is to describe the main physiological mechanisms controlling baro- and chemoreflex function and their role in exercise capacity during HA exposure.
dc.description.sponsorshipAgencia Nacional de Investigación y Desarrollo (ANID), Fondecyt de Iniciación #11220870 y Anillo ACT210083. MR-F. Fondecyt Regular #1230844, Millennium Science Initiative Program ICN2021_004 Fondecyt Regular #1211443. Minera Escondida Ltda, MEL2203
dc.identifier.doi10.3389/fphys.2024.1422927
dc.identifier.issn1664042X
dc.identifier.urihttps://repositorioabierto.uantof.cl/handle/uantof/628
dc.language.isoen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceFrontiers in Physiology
dc.titleBaroreflex and chemoreflex interaction in high-altitude exposure: possible role on exercise performance
dc.typeArticle
oaire.citation.volume15
organization.identifier.rorUniversidad de Antofagasta
uantof.identificator.centerCentro de Investigación en Fisiología y Medicina de Altura
uantof.identificator.departmentDepartamento Biomédico
uantof.identificator.facultyFacultad de Ciencias de la Salud
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