Baroreflex and chemoreflex interaction in high-altitude exposure: possible role on exercise performance

Vista sencilla de ítem
dc.contributor.authorAlvarez Araos, Pablo
dc.contributor.authorJiménez, Sergio
dc.contributor.authorSalazar Ardiles, Camila
dc.contributor.authorNúñez Espinosa, Cristian
dc.contributor.authorPaez, Valeria
dc.contributor.authorRodriguez Fernandez, Maria
dc.contributor.authorRaberin, Antoine
dc.contributor.authorMillet, Gregoire P.
dc.contributor.authorIturriaga, Rodrigo
dc.contributor.authorAndrade, David C.
dc.date.accessioned2026-01-23T15:36:16Z
dc.date.available2026-01-23T15:36:16Z
dc.date.issued2024
dc.description.abstractThe hypoxic chemoreflex and the arterial baroreflex are implicated in the ventilatory response to exercise. It is well known that long-term exercise training increases parasympathetic and decreases sympathetic tone, both processes influenced by the arterial baroreflex and hypoxic chemoreflex function. Hypobaric hypoxia (i.e., high altitude [HA]) markedly reduces exercise capacity associated with autonomic reflexes. Indeed, a reduced exercise capacity has been found, paralleled by a baroreflex-related parasympathetic withdrawal and a pronounced chemoreflex potentiation. Additionally, it is well known that the baroreflex and chemoreflex interact, and during activation by hypoxia, the chemoreflex is predominant over the baroreflex. Thus, the baroreflex function impairment may likely facilitate the exercise deterioration through the reduction of parasympathetic tone following acute HA exposure, secondary to the chemoreflex activation. Therefore, the main goal of this review is to describe the main physiological mechanisms controlling baro- and chemoreflex function and their role in exercise capacity during HA exposure.
dc.description.sponsorshipAgencia Nacional de Investigación y Desarrollo (ANID), Fondecyt de Iniciación #11220870 y Anillo ACT210083. MR-F. Fondecyt Regular #1230844, Millennium Science Initiative Program ICN2021_004 Fondecyt Regular #1211443. Minera Escondida Ltda, MEL2203
dc.identifier.doi10.3389/fphys.2024.1422927
dc.identifier.issn1664-042X
dc.identifier.urihttps://repositorioabierto.uantof.cl/handle/uantof/628
dc.language.isoen
dc.publisherFrontiers Media SA
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceFrontiers in Physiology
dc.subjectchemoreflex
dc.subjectcarotidbody
dc.subjectBaroreflex
dc.subjectbaroreceptors
dc.subjecthighaltitudeexposure
dc.subjectbreathing
dc.subjectventilation
dc.subjectarterial pressure
dc.titleBaroreflex and chemoreflex interaction in high-altitude exposure: possible role on exercise performance
dc.typeArticle
oaire.citation.volume15
organization.identifier.rorhttps://ror.org/04eyc6d95
organization.legalNameUniversidad de Antofagasta
uantof.identificator.centerCentro de Investigación en Fisiología y Medicina de Altura
uantof.identificator.departmentDepartamento Biomédico
uantof.identificator.facultyFacultad de Ciencias de la Salud
uantof.identificator.instituteInstituto Antofagasta
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
fphys-15-1422927.pdf
Tamaño:
1.37 MB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed to upon submission
Descripción:
Descargar
Colecciones
Departamento Biomédico
Centro de Fisiología y Medicina de Altura