Exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive

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dc.contributor.authorAndrade, David C.
dc.contributor.authorDíaz‑Jara, Esteban
dc.contributor.authorToledo, Camilo
dc.contributor.authorSchwarz, Karla G.
dc.contributor.authorPereyra, Katherin V.
dc.contributor.authorDíaz, Hugo S.
dc.contributor.authorMarcus, Noah J.
dc.contributor.authorOrtiz, Fernando C.
dc.contributor.authorRíos‑Gallardo, Angélica P.
dc.contributor.authorOrtolani, Domiziana
dc.contributor.authorDel Rio, Rodrigo
dc.date.accessioned2025-06-17T20:25:56Z
dc.date.available2025-06-17T20:25:56Z
dc.date.issued2021
dc.description.abstractMounting an appropriate ventilatory response to exercise is crucial to meeting metabolic demands, and abnormal ventilatory responses may contribute to exercise-intolerance (EX-inT) in heart failure (HF) patients. We sought to determine if abnormal ventilatory chemoreflex control contributes to EX-inT in volume-overload HF rats. Cardiac function, hypercapnic (HCVR) and hypoxic (HVR) ventilatory responses, and exercise tolerance were assessed at the end of a 6 week exercise training program. At the conclusion of the training program, exercise tolerant HF rats (HF + EX-T) exhibited improvements in cardiac systolic function and reductions in HCVR, sympathetic tone, and arrhythmias. In contrast, HF rats that were exercise intolerant (HF + EX-inT) exhibited worse diastolic dysfunction, and showed no improvements in cardiac systolic function, HCVR, sympathetic tone, or arrhythmias at the conclusion of the training program. In addition, HF + EX-inT rats had impaired HVR which was associated with increased arrhythmia susceptibility and mortality during hypoxic challenges (~ 60% survival). Finally, we observed that exercise tolerance in HF rats was related to carotid body (CB) function as CB ablation resulted in impaired exercise capacity in HF + EX-T rats. Our results indicate that: (i) exercise may have detrimental effects on cardiac function in HF-EX-inT, and (ii) loss of CB chemoreflex sensitivity contributes to EX-inT in HF.
dc.description.sponsorshipFONDECYT grants 1180172 FONDECYT 1210940 FONDECYT 3190659 FONDECYT 3210564 Basal Centre of Excellence in Aging and Regeneration (AFB 170005) t Lithium in Health and Disease’ from the Sociedad Química y Minera de Chile (SQM) to RDR.
dc.identifier.doi10.1038/s41598-021-93791-8
dc.identifier.issn2045-2322
dc.identifier.urihttps://repositorioabierto.uantof.cl/handle/uantof/527
dc.language.isoen
dc.publisherNature Research
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientific Reports
dc.titleExercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive
dc.typeArticle
oaire.citation.issue1
oaire.citation.volume11
organization.identifier.rorhttps://ror.org/04eyc6d95
organization.legalNameUniversidad de Antofagasta
uantof.identificator.centerCentro de Investigación en Fisiología y Medicina de Altura
uantof.identificator.facultyFacultad de Ciencias de la Salud
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