New insights into the pathogenesis of SARS-CoV-2 during and after the COVID- 19 pandemic

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dc.contributor.authorJonatan J. Carvajal
dc.contributor.authorValeria García Castillo
dc.contributor.authorShelsy V. Cuellar
dc.contributor.authorClaudia P. Campillay Véliz
dc.contributor.authorCamila Salazar Ardiles
dc.contributor.authorAndrea M. Avellaneda
dc.contributor.authorChristian A. Muñoz
dc.contributor.authorAngello Retamal Díaz
dc.contributor.authorSusan M. Bueno
dc.contributor.authorPablo A. González
dc.contributor.authorAlexis M. Kalergis
dc.contributor.authorMargarita K. Lay
dc.date.accessioned2026-03-11T19:58:41Z
dc.date.available2026-03-11T19:58:41Z
dc.date.issued2024
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the respiratory distress condition known as COVID-19. This disease broadly affects several physiological systems, including the gastrointestinal, renal, and central nervous (CNS) systems, significantly influencing the patient’s overall quality of life. Additionally, numerous risk factors have been suggested, including gender, body weight, age, metabolic status, renal health, preexisting cardiomyopathies, and inflammatory conditions. Despite advances in understanding the genome and pathophysiological ramifications of COVID-19, its precise origins remain elusive. SARS-CoV-2 interacts with a receptor-binding domain within angiotensin-converting enzyme 2 (ACE2). This receptor is expressed in various organs of different species, including humans, with different abundance. Although COVID-19 has multiorgan manifestations, the main pathologies occur in the lung, including pulmonary fibrosis, respiratory failure, pulmonary embolism, and secondary bacterial pneumonia. In the post- COVID-19 period, different sequelae may occur, which may have various causes, including the direct action of the virus, alteration of the immune response, and metabolic alterations during infection, among others. Recognizing the serious adverse health effects associated with COVID-19, it becomes imperative to comprehensively elucidate and discuss the existing evidence surrounding this viral infection, including those related to the pathophysiological effects of the disease and the subsequent consequences. This review aims to contribute to a comprehensive understanding of the impact of COVID-19 and its long-term effects on human health.
dc.description.sponsorshipGobierno Regional de Antofagasta a través del Fondo de Innovación para la Competitividad FIC-R 2017 (Código BIP: 30488811–0) Copec-UC 2020.R.001 Agencia Nacional de Investigación y Desarrollo (ANID) - Programa Iniciativa Científica Milenio, Instituto Milenio de Inmunología e Inmunoterapia (ICN09_016/ICN 2021_045; anterior P09/016-F) Fondecyt Regular n.° 1240971 Plan de Fortalecimiento del VRIIP, código ANT20992.
dc.identifier.doi10.3389/fimmu.2024.1363572
dc.identifier.issn16643224
dc.identifier.urihttps://repositorioabierto.uantof.cl/handle/uantof/652
dc.language.isoen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceFrontiers in Immunology
dc.titleNew insights into the pathogenesis of SARS-CoV-2 during and after the COVID- 19 pandemic
dc.typeArticle
oaire.citation.volume15
organization.identifier.rorUniversidad de Antofagasta
uantof.identificator.centerCentro de Investigación en Inmunología y Biotecnología en Antofagasta
uantof.identificator.departmentDepartamento de Biotecnología
uantof.identificator.facultyFacultad de Ciencias del Mar y Recursos Biológicos
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Departamento de Biotecnología
Centro de Fisiología y Medicina de Altura
Departamento Biomédico
Departamento de Tecnología médica