High Prevalence and Genetic Diversity of Human Norovirus Among Children Under 5 Years Old with Acute Gastroenteritis at the Dr. Leonardo Guzmán Regional Hospital, Antofagasta, Chile, 2019

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dc.contributor.authorAvellaneda, Andrea M
dc.contributor.authorCampillay-Veliz, Claudia P
dc.contributor.authorReyes, Daniela C
dc.contributor.authorHerrera, Daniel
dc.contributor.authorMunoz, Christian A
dc.contributor.authorVinje, Jan
dc.contributor.authorLay, Margarita K
dc.date.accessioned2026-08-28T01:44:17Z
dc.date.available2026-08-28T01:44:17Z
dc.date.issued2025
dc.description.abstractAcute gastroenteritis (AGE) has one of the highest rates of morbidity and mortality among children under five years old worldwide. It is estimated that 1.7 billion cases of childhood diarrheal diseases occur annually, leading to up to 443,832 deaths. Approximately 90% of these cases are viral, with human norovirus being the main cause in countries that have implemented rotavirus vaccines. The objective of this study was to describe the prevalence and genetic diversity of norovirus in child outpatients and inpatients under five years old at the Regional Hospital of Antofagasta. From 1 January to 31 October 2019, a total of 121 stool samples were collected to detect the presence of norovirus GI and GII using Taqman™-based real-time RT-PCR. Norovirus RNA was detected in 50 (41.3%) samples, of which 96% were typed as GII.4 Sydney (42% GII.4 Sydney[P16] and 54% GII.4 Sydney[P4 New Orleans]). Furthermore, most (92%) of the positive specimens were from children under two years of age and a majority were detected in April (38%) and May (20%). Our findings highlight the high burden of norovirus in hospitalized children with AGE and the importance of molecular strain surveillance to support vaccine development.
dc.description.sponsorshipInnovation Fund for Competitiveness FIC-R 2017 [30488811-0]; Innovation Fund for Competitiveness FIC-R [ICN2021_045]; Millennium Institute in Immunology and Immunotherapy [FOVI240251]; National Agency for Research and Development of Chile
dc.identifier.doi10.3390/v17060794
dc.identifier.issn1999-4915
dc.identifier.urihttps://repositorioabierto.uantof.cl/handle/uantof/724
dc.language.isoen
dc.publisherMDPI
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceViruses
dc.subjectacute gastroenteritis
dc.subjecthuman norovirus
dc.subjectgenogroups
dc.subjectgenotypes
dc.subjectGII.4 variants
dc.titleHigh Prevalence and Genetic Diversity of Human Norovirus Among Children Under 5 Years Old with Acute Gastroenteritis at the Dr. Leonardo Guzmán Regional Hospital, Antofagasta, Chile, 2019
dc.typeArticle
oaire.citation.volume17
oaire.citationIssue6
organization.identifier.rorhttps://ror.org/04eyc6d95
organization.legalNameUniversidad de Antofagasta
uantof.identificator.centerCentro de Investigación en Inmunología y Biotecnología Biomédica de Antofagasta
uantof.identificator.departmentDepartamento de Biotecnología
uantof.identificator.departmentDepartamento de Tecnología Médica
uantof.identificator.facultyFacultad de Ciencias del Mar y Recursos Biológicos
uantof.identificator.facultyFacultad de Ciencias de la Salud
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