Role of human herpesvirus homologs of infected cell protein 27 (ICP27) in the biogenesis, processing, and maturation of mRNAs

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dc.contributor.authorSoto-Machuca, Abel A
dc.contributor.authorOrtiz, Gerardo E
dc.contributor.authorCarbone-Schellman, Javier
dc.contributor.authorPasten-Ferrada, Ignacio A
dc.contributor.authorRetamal-Diaz, Angello
dc.contributor.authorKalergis, Alexis M
dc.contributor.authorGonzalez, Pablo A
dc.date.accessioned2026-08-28T01:25:11Z
dc.date.available2026-08-28T01:25:11Z
dc.date.issued2025
dc.description.abstractHerpesviruses are enveloped viruses with large double-stranded DNAgenomes that are highly prevalent in the human population and elicit numeroustypes of clinical manifestations, from mild to severe. These viruses are classified intothree subfamilies: alpha-, beta-, and gammaherpesvirinae, all capable of establishinglife-long persistent infections in the host. As strict intracellular parasites, these viruseshave evolved molecular determinants to support and modulate viral and host genetranscription processes during infection and the translation of messenger RNAs (mRNAs)to synthesize proteins that participate in cellular pathways promoting their replicationcycles and virion formation. Notably, some of these proteins have functional RNA-binding domains consisting of arginine-glycine-glycine (RGG) amino acid (aa) sequencesthat, when methylated, regulate their nucleic acid-binding capacities and can influencethe export of mRNAs lacking introns from the nucleus into the cytoplasm. Additionaldomains and motifs in these proteins mediate their interactions with regulatory proteinsrelated to RNA splicing, either promoting or repressing mRNA processing. Notably, allhuman herpesviruses (HHVs) encode in their genomes proteins that share homologywith infected cell protein 27 (ICP27) of herpes simplex virus type 1 (HSV-1), which cansignificantly impact the biogenesis of mRNAs and their processing during infection. Here,we review and discuss the roles of ICP27 and the corresponding homologs encoded indifferent human herpesviruses, focusing on their similarities and differences in structureand function. A more profound knowledge of the role of key viral factors requiredfor effective herpesvirus replication could aid in the design and identification of novelantivirals to treat the diseases produced by these viruses.
dc.description.sponsorshipAgencia Nacional de Investigacion y Desarrollo (ANID)-Millennium Science Initiative Program ICN2021_045; FONDECYT 1240971; ANID 1231851, 21241472
dc.identifier.doi10.1128/mbio.00291-25
dc.identifier.issn2150-7511
dc.identifier.urihttps://repositorioabierto.uantof.cl/handle/uantof/719
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcemBio
dc.subjectRNA transcription
dc.subjectRNA modification
dc.subjectmRNA export
dc.subjectmRNA translation
dc.subjecthuman herpesviruse
dc.titleRole of human herpesvirus homologs of infected cell protein 27 (ICP27) in the biogenesis, processing, and maturation of mRNAs
dc.typeReview
oaire.citation.volume16
oaire.citationIssue4
organization.identifier.rorhttps://ror.org/04eyc6d95
organization.legalNameUniversidad de Antofagasta
uantof.identificator.centerCentro de Investigación en Inmunología y Biotecnología Biomédica de Antofagasta
uantof.identificator.departmentDepartamento de Biotecnología
uantof.identificator.facultyFacultad de Ciencias del Mar y Recursos Biológicos
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