Colorectal adenomas and MAFLD: a cross-sectional study in a Hispanic screening cohort

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dc.contributor.authorAlejandro Villalón
dc.contributor.authorLuis Antonio Díaz
dc.contributor.authorEduardo Fuentes López
dc.contributor.authorJavier Villalón
dc.contributor.authorFernando Villalon
dc.contributor.authorGustavo Ayares
dc.contributor.authorBárbara Yañez
dc.contributor.authorRoberto Candia
dc.contributor.authorJuan Pablo Arab
dc.contributor.authorMarco Arrese
dc.date.accessioned2025-12-22T13:33:43Z
dc.date.available2025-12-22T13:33:43Z
dc.date.issued2022
dc.description.abstractAims: Prior evidence demonstrates an association between non-alcoholic fatty liver disease (NAFLD) and colorectal adenomas (CRA) risk. However, information using the new definition of the disease [i.e., metabolic dysfunction-associated fatty liver disease (MAFLD)] is scarce. We aimed to assess the relationship between MAFLD and CRA risk. Methods: We conducted a cross-sectional study including patients from three university centers in Chile who underwent a colonoscopy for colorectal cancer screening and abdominal imaging study. We obtained sociodemographic and clinical data, and we performed univariate and multivariable regression analyses. Results: In total, 895 patients were included; 42% were male, the mean age was 59.9 ± 9.3 years, and 37.8% (338) had CRA. Patients harboring polyps were predominantly males (48.2% vs. 38.2%, P = 0.002), older (61.6 ± 8.7 years vs. 58.9 ± 9.5 years, P < 0.001), and exhibited a higher body weight than controls [75 (66-88) kg vs. 72 (63-82.3) kg, P = 0.002]. Fifty-six percent of patients showed hepatic steatosis in imaging studies and 54.4% met MAFLD diagnostic criteria. The adenoma detection rate was higher in the MAFLD group compared to controls (46.4% vs. 27.5%, P < 0.001). In the multivariable analysis, MAFLD was significantly associated with the presence of CRA (odds ratio = 2.32; 95%CI: 1.68-3.19, P < 0.0001). There were no statistically significant differences of histopathological characteristics of the adenomas according to the presence of MAFLD. Conclusion: The present study shows that, in Chilean Hispanic subjects, MAFLD is associated with an increased risk of CRA. This information may be useful to design specific screening colonoscopy recommendations in MAFLD patients.
dc.description.sponsorshipFondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT 1191145 y 1200227) Agencia Nacional de Investigación y desarrollo, ANID, (ANID ACE 210009) European Union’s Horizon 2020 Research and Innovation Program, no. 825510.
dc.identifier.doi10.20517/mtod.2021.17
dc.identifier.issn27696375
dc.identifier.urihttps://repositorioabierto.uantof.cl/handle/uantof/586
dc.language.isoen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceMetabolism and Target Organ Damage
dc.titleColorectal adenomas and MAFLD: a cross-sectional study in a Hispanic screening cohort
dc.typeArticle
oaire.citation.volume2
organization.identifier.rorUniversidad de Antofagasta
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