Dietary supplementation of a sulforaphane-enriched broccoli extract protects the heart from acute cardiac stress
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2020
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Cardiac arrythmias play a critical role in several pathological conditions. Importantly, increased arrhythmic risk
is associated with systemic oxidative stress and activation of the autonomic nervous system. Thus, we hypothesized
that dietary antioxidant supplementation may help in reducing cardiac stress-induced arrhythmias. Sulforaphane
(SFN), an isothiocyanate present in Brassicaceaes, is recognized as a powerful health-promoting
compound with known antioxidant properties. Then, we aimed to generate a broccoli extract (BE) enriched in
SFN and determine whether oral BE supplementation induced cardio-protection during acute cardiac stress in
rats. BE decreases cardiac sympathetic drive and increases parasympathetic cardiac modulation as evidenced by
heart rate variability (HRV) shifts. In addition, isoproterenol-induced cardiac stress (a sympathomimetic agent)
induced a ~ 4-fold increase in arrhythmia incidence and this effect was almost completely abolished by BE
treatment. In conclusion, dietary supplementation with a BE regulates cardiac autonomic drive and protects the
heart from acute cardiac stress.